Dr. Wang, how does your team approach these pregnancy-related projects?
The importance of this kind of information is something that resonates with all of us. The need for these investigations isn’t going away anytime soon.
To help sponsors and regulatory agencies answer these types of questions, we created a capability called the Dynamic Assessment of Pregnancies and Infants, or DAPI.
DAPI has the powerful capability to link the health data of women and their infants within the Optum claims-based research database. It includes about 200,000 pregnancies per calendar year.
The resulting database allows researchers to track women’s exposures, medications they took before and during pregnancy, and link the exposures to infants in utero.
We examine these exposures in relation to pregnancy outcomes and infant health outcomes. The DAPI dataset offers unparalleled depth and breadth for answering questions about maternal and infant health.
The de-identified dataset we utilize includes live and non-live pregnancy outcomes. We can pull in additional information from medical records, like vital signs, comorbidities and lifestyle variables. In-hospital labor, delivery care and medication administrations can also be captured in detail.